Pharmacokinetics of phenytoin: unaltered by enalapril and amlodipine in rhesus monkeys.
نویسندگان
چکیده
A cross over single and multiple dose study was carried out to find out pharmacokinetic interactions between diphynylhydantoin (DPH) (35 mg/kg, p.o.) and antihypertensives enalapril (1.6 mg/kg; p.o.) and amlodipine (0.4 mg/kg, p.o.) in rhesus monkeys. Neither the plasma concentrations nor the pharmacokinetic parameters of DPH were altered by coadministration of enalapril or amlodipine, suggesting that enalapril and amlodipine can be safely administered to epileptic patients receiving phenytoin.
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ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 43 2 شماره
صفحات -
تاریخ انتشار 1999